Thermo Scientific Automates Chromatography Conductivity
The DynaChrom system uses model-based control to improve gradient precision in pharmaceutical manufacturing.
Updated on Sept. 19, 2026 in Biotech
Thermo Scientific has released the DynaChrom Single-Use Chromatography System, which uses closed-loop, model-based control to manage conductivity during purification processes. The system is designed to improve consistency in pharmaceutical production by automatically correcting deviations in real time.
Why it matters
This system addresses manual handling inefficiencies in biomanufacturing by integrating automated conductivity management into existing facility workflows. The technology aims to increase product recovery and impurity clearance while reducing the need for extensive buffer storage.
The system operates at flow rates from 6 to 1,980 L/hr, using closed-loop, model-based control to manage both linear and step gradients. It integrates directly with the TruChrom automation platform on the Emerson DeltaV Distributed Control System (DCS) to minimize overshoot and settling time.
The players
Thermo Scientific
A subsidiary of Thermo Fisher Scientific that specializes in laboratory equipment, analytical instruments, and software for life sciences.
Emerson
A global technology company providing software and engineering services, known for its DeltaV distributed control systems in industrial automation.
The details
The DynaChrom system functions by continuously monitoring conductivity and applying model-based control algorithms to adjust gradient delivery. By integrating with the Emerson DeltaV DCS — a system used for process control and automation in industrial plants — the hardware corrects conductivity fluctuations in real time. This automated approach limits manual intervention, which stabilizes peak resolution and improves overall impurity clearance during liquid chromatography, a method used to separate components in a mixture.
Timeline
September 19, 2026: Official details regarding the system capabilities were published.
The Tech Race
The integration of DynaChrom with the Emerson DeltaV platform marks a move toward standardized, model-based automation in bioprocessing suites. This follows an industry trend of moving away from manual buffer handling toward closed-loop systems that prioritize consistent impurity clearance and high-resolution separation.
Manufacturers can deploy this system to reduce their physical facility footprint and the complexity of buffer storage requirements. The technology is designed to integrate into existing automated facility workflows, requiring compatibility with current DeltaV control setups.
The takeaway
The transition to model-based, automated chromatography marks a significant shift in how biomanufacturers maintain precise gradient control. Industry professionals should monitor subsequent performance benchmarks compared to manual systems to gauge the actual impact on production cycle times.
Further reading
For broader trends in bioprocessing infrastructure, see the latest updates on Biotech.
Source note: This article includes information reported by Pharmaceuticalonline.
